Abstract
The founding cell of the hematopoietic hierarchy, the hematopoietic stem cell (HSC), arises de novo from the major arteries of the mouse embryo from E10.5. HSCs form from a sub-set of endothelial cells during a process known as the endothelial-to-hematopoietic transition (EHT) and go on thereafter to colonize the fetal liver (FL) where they proliferate. Previous work has shown that the first HSCs (pre-HSCs) are enriched in the VE-Cadherin+CD45+ population of the E11.5 dorsal aorta (DA). By E14.5 however, FL HSCs can be purified using the SLAM-LSK markers (CD150+Lin-ScaI+c-kit+) characteristic of adult-type bone marrow HSCs.
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