Abstract
Meeting abstracts Simply stated, clinical response to an immunotherapy is proportional to the product of three quantities: the total number of tumor-infiltrating lymphocytes (TILs), the proportion of tumor cells that can be recognized by these TILs, and the cytotoxic efficacy of TILs directed
Highlights
Clinical response to an immunotherapy is proportional to the product of three quantities: the total number of tumor-infiltrating lymphocytes (TILs), the proportion of tumor cells that can be recognized by these TILs, and the cytotoxic efficacy of TILs directed against tumor cells
Recent clinical responses to Ipilimumab illustrate that TILs recognize tumor cells and that modifying immune checkpoints can increase the total number of T lymphocytes
Until we identify which of the many putative or potentially undiscovered local biochemical mechanisms limit the cytotoxic efficacy of TILs, the subset of patients that respond to these immune checkpoint modulators will be limited, as is the current state for Ipilimumab
Summary
Clinical response to an immunotherapy is proportional to the product of three quantities: the total number of tumor-infiltrating lymphocytes (TILs), the proportion of tumor cells that can be recognized by these TILs, and the cytotoxic efficacy of TILs directed against tumor cells. Identifying local mechanisms for tumor-derived immunosuppression: an integrated phenotypic screening approach
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