Abstract
Adult-onset diabetes (DM) can be classified into 5 subtypes characterized by distinct progression in dysglycemia and complications. Five variables (age at diagnosis, glycated hemoglobin [HbA1c], body mass index [BMI], C-peptide, glutamic acid decarboxylase antibodies [GADA]) were used to cluster 7,017 participants with diabetes from the Outcome Reduction with Initial Glargine INtervention (ORIGIN) into 1) severe auto-immune DM (SAID, n=241), 2) severe insulin-deficient DM (SIDD, n=1,594), 3) severe insulin-resistant DM (SIRD, n=914), 4) mild obesity-related DM (MOD, n=1,595), and 5) mild age-related DM (MARD, n=2,673).
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