Identifying and Study of some of Phytochemical compounds and Anti-Jaundice Activity for powder of leaves and seeds of Moringa oleifera in male albino rats.

Abstract

The present study aimed to revealing and identifying some of phytochemical compounds, bioactive fatty acids and antioxidants for powder of leaves and seeds of Moringa oleifera that cultivated in Iraq which have been many identified by using modern techniques such as gas chromatography mass spectrometry (GC-MS) technique. And then study and test the preventive and Therapy effects for powder of leaves and seeds in present study against hepatotoxicity that induced by carbon tetrachloride (CCl4) and against jaundice. These effects were tested by measuring total bilirubin concentrations of total bilirubin and γ-glutamyl transferase (GGT) in serum of normal male rats, exposed to CCl4 and that treated with powder of leaves and seeds of Moringa oleifera along the period of experiment (30) days, used (20) albino male rats divide to (4) groups, that is meaning (5) rats for each group. The rats group that exposed to CCl4 caused a significant increase (P<0.05) in concentrations of total bilirubin and GGT enzyme in comparison with normal control group. Whereas the animals which exposed to CCl4 then treated with powder of leaves and seeds of Moringa oleifera lead to significant decrease (P<0.05) in total bilirubin and GGT enzyme concentration in comparison with the group that exposed to CCl4 only. It could be concluded of this study that using powder of leaves and seeds of Moringa oleifera may be have Preventive and therapeutic effects against damage and hepatotoxicity, subsequently, anti-jaundice activity through its nutritional and antioxidant influences for remove of free radicals and repairing cellular and tissues from toxic damage