Abstract
The prototype CoH35211 strain of Guaroa virus contained 2 different plaque populations when French or Mann agarose were used for solidifying the overlay medium. The pl1L (large) and p12S (small) plaque variants were similar with respect to pathogenicity for suckling mice (SM), titers achieved in SM brains after intracranial inoculation and time of appearance of plaques under agarose overlay. The prototype CoH35211 strain and the 2 plaque variants were indistinguishable by complement-fixation and plaque-neutralization tests. However, the 2 plaque variants differed with respect to plaque size and sensitivity to the inhibitory effects of sulfated agar polysaccharides. The only different serological relationship was a “one-way” cross-reaction between p12S antibody and California encephalitis and Tahyna viruses by plaque-neutralization test.
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