Abstract
Meeting abstracts Antigen-specific adaptive T cell therapy or T cell receptor (TCR) gene therapy is promising as a next generation tumor therapy. For the therapy, the production of tumor-specific T cells or their TCRs is prerequisite. Exploration of tumor-associated antigens, antigen-specific T
Highlights
Antigen-specific adaptive T cell therapy or T cell receptor (TCR) gene therapy is promising as a generation tumor therapy
Exploration of tumor-associated antigens, antigen-specific T cells or their TCR is usually restricted to the population with major HLA haplotypes, such as HLA-A24 for the Southeast Asian or HLA-A2 for Caucasian population
We found the clonal expansion of T cells in tumorinfiltrating lymphocytes (TIL), but not in splenic T cells and detected tumor-specific T cells in those clonally expanded cells
Summary
Antigen-specific adaptive T cell therapy or T cell receptor (TCR) gene therapy is promising as a generation tumor therapy. Identification of tumor-specific T cell receptors from primary tumor-infiltrating lymphocytes Hiroyuki Kishi*, Hiroshi Hamana, Kiyomi Shitaoka, Atsushi Muraguchi
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