Abstract
Cancer is still one of the leading causes of death at present. The development of immunotherapies based on the identification of tumor antigens provides a promising option of cancer therapy. Tumor antigens are the targets that could be recognized by T cells or antibodies and thus elicit immune response in cancer patients. Since tumor antigens are exclusively expressed or over expressed on tumor cells, the immune responses against tumor antigens would only destroy tumor cells but not normal cells. Cancer immunotherapies discussed in this chapter refer to therapeutic monoclonal antibodies, adoptive T cell therapy, and therapeutic vaccines. With the superiority of high specificity, cancer immunotherapies may act as a personalized treatment against cancer to overcome the immune suppression environment of cancer patients as well as the unexpected side effects.KeywordsTumor antigenImmune responseMonoclonal antibodyVaccineImmunotherapyImmunology
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