Identification of the TIMP-2 binding site on the gelatinase A hemopexin C-domain by site-directed mutagenesis and the yeast two-hybrid system.

Abstract

Annals of the New York Academy of SciencesVolume 878, Issue 1 p. 747-753 Identification of the TIMP-2 Binding Site on the Gelatinase A Hemopexin C-Domain by Site-Directed Mutagenesis and the Yeast Two-Hybrid System CHRISTOPHER M. OVERALL, Corresponding Author CHRISTOPHER M. OVERALL Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3 Address for correspondence: Dr. C.M. Overall, University of British Columbia, 2199 Westbrook Mall, Vancouver, B.C., Canada V6T 1Z3. Phone, 604/822-2958; fax, 604/822-3562; e-mail, [email protected]Search for more papers by this authorANGELA E. KING, ANGELA E. KING Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorHEATHER F. BIGG, HEATHER F. BIGG Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorANGUS McQUIBBAN, ANGUS McQUIBBAN Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorJULIET ATHERSTONE, JULIET ATHERSTONE Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorDOUGLAS K. SAM, DOUGLAS K. SAM Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorALDRICH D. ONG, ALDRICH D. ONG Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorTIM T.Y. LAU, TIM T.Y. LAU Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorU. MARGARETHA WALLON, U. MARGARETHA WALLON Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorYVES A. DeCLERCK, YVES A. DeCLERCK Division of Hematology-Oncology, Childrens Hospital Los Angeles and University of Southern California, Los Angeles, California, USASearch for more papers by this authorERIC TAM, ERIC TAM Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this author CHRISTOPHER M. OVERALL, Corresponding Author CHRISTOPHER M. OVERALL Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3 Address for correspondence: Dr. C.M. Overall, University of British Columbia, 2199 Westbrook Mall, Vancouver, B.C., Canada V6T 1Z3. Phone, 604/822-2958; fax, 604/822-3562; e-mail, [email protected]Search for more papers by this authorANGELA E. KING, ANGELA E. KING Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorHEATHER F. BIGG, HEATHER F. BIGG Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorANGUS McQUIBBAN, ANGUS McQUIBBAN Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorJULIET ATHERSTONE, JULIET ATHERSTONE Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorDOUGLAS K. SAM, DOUGLAS K. SAM Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorALDRICH D. ONG, ALDRICH D. ONG Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorTIM T.Y. LAU, TIM T.Y. LAU Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorU. MARGARETHA WALLON, U. MARGARETHA WALLON Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this authorYVES A. DeCLERCK, YVES A. DeCLERCK Division of Hematology-Oncology, Childrens Hospital Los Angeles and University of Southern California, Los Angeles, California, USASearch for more papers by this authorERIC TAM, ERIC TAM Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Search for more papers by this author First published: 06 February 2006 https://doi.org/10.1111/j.1749-6632.1999.tb07780.xCitations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume878, Issue1INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONSJune 1999Pages 747-753 RelatedInformation