Abstract
Two main urinary metabolites of 6K-PGF 1α were isolated after intravenous injection of this compound into adult male Wistar rats. The structures were identified as: dinor 6K-PGF 1α and dinor ω-1-hydroxy 6K-PGF 1α. The structures of these two novel products were identified by gas chromatographymass spectrometry of the methyl and ethyl ester derivatives of the O-methyl-oxime trimethylsilyl derivatives and the methyl ester O-methyloxime t-Butyl-dimethylsilyl ether derivatives. These results indicate that the main pathway of metabolism of 6K-PGF 1α in vivo is via β-and ω-oxidation and not via the prostaglandin 15-hydroxydehydrogenase pathway in this species.
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