Abstract
Spermatogenic cells expressing autoantigens have been identified using autoantibodies induced against homologous testis tissue in combination with a Staphylococcus Cowan I rosetting technique. The autoantigens first appeared in early pachytene spermatocytes and were present in the spermatogenic cells up to late spermiogenesis. The highest levels of autoantigens were seen in the midpachytene spermatocytes and the late spermatids. These autoantigens probably play a role in the vigorous granulomatotic reactions caused by sperm outside the testis and in the production of autoantibodies after vasectomy.
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