Abstract
Abstract The samples of plant material suspected to contain new psychoactive substances are very often the subject of chemical-toxicological analyses. Gas chromatography-mass spectrometry (MS), liquid chromatography-quadrupole time-of-flight-MS, and liquid chromatography-tandem MS were applied with the aim to identify synthetic cannabinoid, methyl 2-{[1-(cyclohexylmethyl)-1H-indol-3-yl] formamido}-3-methylbutanoate (MMB-CHMICA) without the analytical standard, which is very often the case when a new drug arrives. The structure of compound was also confirmed by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and conformational analysis. After identification, methanolic extract of plant material containing MMB-CHMICA was successfully used for developing a multiple reaction monitoring method on liquid chromatography-tandem MS instrument. The optimization procedure is shown in detail. The complete fragmentation pattern and also the optimization of the extraction procedure of MMB-CHMICA from plant material were shown. The obtained data are useful for forensic, toxicological, and clinical purposes.
Highlights
IntroductionMore than 1,000 new psychoactive substances (NPSs) have emerged on illicit drug markets [1]
In the last decade, more than 1,000 new psychoactive substances (NPSs) have emerged on illicit drug markets [1]
In the Republic of Serbia, MMB-CHMICA is under control since 2017 after our research presented in this article
Summary
More than 1,000 new psychoactive substances (NPSs) have emerged on illicit drug markets [1] Their number and chemical diversity are constantly increasing. Identification of synthetic cannabinoid MMB-CHMICA 1251 known as “Smart Shops” [3] using product terms such as “legal highs,” “herbal highs,” “research chemicals,” “plant food,” “herbal incense,” or “bath salts” as a way to circumvent laws governing their sale. They exist as powders, pellets, tablets, liquids, and herbal material and frequently are labeled as “Not for Human Consumption” [4,5,6]. They are accompanied by e-liquids, impregnated letters, and blotting papers as new product formulations [7]
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