Abstract
The G-quadruplexes play a biological role in DNA telomere ends,the purine-rich DNA strands of the oncogenic promoterelements such as c-myc and c-kit, and RNA 5'-untranslatedregion (UTR) in close to translational start sites. Telomereslocated at the ends of eukaryotic chromosomes are com-posed of the tandem DNA repeats of guanine-rich sequencesand essential for chromosome stability. They appear to playa critical role in cellular aging and cancer.
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