Abstract
In the present study, ten different sea weeds from Visakhapatnam sea coast, India, were selected for the identification of potential immunomodulatory property using Balb/(c) mice. The aqueous extract of Sargassum vulgare, Padina tetrastromatica, and Amphiroa fragilissima exhibited alleviated levels against ovalbumin-specific IgG and IgM antibody responses using Balb/(c) mice for immunomodulator properties. The IgG and IgM levels were determined by enzyme-linked immunosorbent assay (ELISA). The seaweed aqueous extracts have been further subjected to activity-guided organic solvent (chloroform, ethyl acetate, and ethanol) fractionation. The ethanolic fraction of these sea weeds has shown the highest activity. The results obtained in this study shown that ethanolic extracts of Padina tetrastromatica enhanced levels of IgG and IgM when compared to other solvent extracts. Immunomodulation results in fine tuning the responses of different components of immune system. The putative immunomodulatory principles present in the ethanolic fractions of these seaweeds can be therapeutically useful as a remedy to treat autoimmune diseases, hypersensitivity, etc.
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