Abstract
Summary: Thalassaemiais a congenital hemolytic disorder caused by partial or complete deficiency of ? or ? globin chain synthesis. The disease is treated by lifelong red cell transfusion. So they are at high risk of developing allo-antibodies, resulting difficult to obtain compatible blood, results in, haemolysis & occasionally life threatening events.Objectives: To find out the frequency of Rhesus alloantibodies among the thalassaemic patients.Methods: This cross sectional study was done in the department of transfusion medicine in Bangabandhu Sheikh Mujib Medical University from 01-07-2010 to 03-07-2011. Sample size was 100 and the data was collected by face to face interview. Purposive sampling method was applied using inclusion & exclusion criteria. Statically analysis of the result was obtained by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-15) (SPSS Inc, Chicago, IL, USA).Result: In the present study all respondent were Rh D-positive. Out of 100 respondents 2 (2.0%) had positive direct Coombsand 6 (6.0%) had positive indirect Coomds test. Out of 6 respondent with Rhesus all-antibody, 4 (66.7%) had anti E antibody, 1(16.7%) had anti c antibody and 1 (16.7%) had non specific antibody.Conclusion: In this study among the 100 respondents of thalassaemic patients who receive regular blood transfusion 6 (6.0%) had developed rhesus allo-antibody among with the most common was Anti E antibody 4 (66.7%). Such information may enable understanding and prevention of this serious and common complication.J MEDICINE July 2016; 17 (2) : 79-83
Highlights
We will investigate the frequency of alloantibodies among patients receiving regular red cell transfusions for thalassemia. This is a cross sectional studywas conducted in the Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University from 1st July 2010 to 30th June 2011. 100 thalassaemia patients were seen and purposive sampling method was applied including both sex and rhesus D antigen positive with age group 2-50 years
It is estimated that 300,000 infants are born with major hemoglobinopathies worldwide in each year of whom 60,000 to 70,000 are beta thalassemia major cases especially inthe Mediterranean area, Middle East, Far East, and East Asia.9Major advances have occurred in the treatment and prevention of thalassemia major.[10]
It is well known that the development of erythrocyte alloantibodies complicates transfusion therapy.4Alloimmunization and autoimmunization are common, serious complications in Asian thalassemia patients, who are affected by donor-recipient RBC antigen mismatch and immunological factors.4,13Alloimmunization to erythrocyte antigens is a frequent complication in transfusion-dependent thalassemia
Summary
It is a serious public health problem throughout the Mediterranean region, the Middle East and the Indian subcontinent, as well as in Southeast Asia and out of approximately 300 million carriers of this hemoglobin disorder worldwide, 55 million live in Southeast Asia.1Thalassemias and hemoglobinopathies are the most common single-gene disorders in humans ona worldwide basis).2,3Thalassemia is acongenital haemolytic disorder caused by partial or complete deficiency of α-or β-. 1. Medical Officer of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. 2. Assistant Professor of Transfusion Medicine, BSMMU, Dhaka. 3. Professor of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka. 4. Student of MD (Final part) Transfusion Medicine, BSMMU, Dhaka
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