Abstract
Studies were performed to determine if prolactin appears in cerebro-spinal fluid (CSF) after intravenous administration to rabbits and if prolactin is a normal constituent of CSF in rats. Intravenous administration of a rat pituitary homogenate containing 250 μg of prolactin to adult female New Zeland white rabbits resulted in the appearance of significant quantities of prolactin in the CSF. In rats prolactin was almost undetectable in CSF on diestrous day 2, but significant quantities of prolactin were present in the CSF on the afternoon of proestrus. These results indicate that prolactin can cross the blood-brain barrier and appear in CSF in quantities that may be sufficient to exert behavioral or short loop feedback effects.
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