Identification of predictive markers for stage progression in primary cutaneous anaplastic large cell lymphoma

Abstract

Aims: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is an indolent CD30+ lymphoproliferative disorder (10-year disease-specific survival 90%) but with frequent cutaneous relapse (40%) and systemic progression occurs in 5–15%. The prognostic markers in pcALCL are unknown although small single-centre studies suggested multiple skin lesions (T2/T3 stage), leg/head involvement and age over 60 years as poor prognostic markers for survival. However, no markers for disease progression have been studied hence we aim to review these markers in pcALCL.