Identification of potential phytochemical lead against diabetic cataract: An insilico approach

Abstract

Cataract is one of the leading causes for blindness among worldwide devoid of effective treatment. Glycation of γ-crystallin under hyperglycemic condition leads to diabetic cataract formation. It is important to design a drug which could inhibit lens protein glycation and prevent the diabetic cataract. The use of plant based natural compounds could have potential bioavailability and fewer toxicity. The current investigation aim is to determine the efficient phytochemicals for inhibition of γ-crystallin glycation. In this study the phytochemicals with anticataract property were virtually screened against γ-crystallin. The potent phytochemicals were filtered based on their interaction site and binding affinity. These phytochemicals were further scrutinized and evaluated with pharmacokinetics, druggability and Pharmacophore feature analysis. Among the phytochemicals, Alizarin (polyketide), Pseudobaptigenin (flavonoid) and Ellagic acid (tannin) are three phytochemicals which had preferred druglike behavior and binding affinity for the inhibition of glycation against γ-crystallin protein. The features of these three phytochemicals could be used as prototype for synthesizing new molecules against diabetic cataract.