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Abstract
The endophytic actimomycete S. platensis RTd22 was cultured in rice solid medium and shaken ISP-2 liquid medium for different periods of time. Extracts and sub-fractions obtained after the chromatographic procedures showed remarkable activity against Staphylococcus aureus ATCC 6538, S. saprophyticus ATCC 15305 and S. aureus ATCC 29213. Some samples from both culture media also showed high activity against the antibiotic-resistant bacteria: vancomycin-intermediate S. aureus Mu50 (VISA), methicillin-resistant S. aureus SA16 (MRSA) and vancomycin-resistant Enterococcus faecium VRE16. Analyses by ESI-MS (AcquityTM UPLC/Waters) of the active fractions allowed the rapid identification of the ionophore antibiotics grisorixin (1), nigericin (2), and mutalomycin (3), structurally related polyether polyketides. The structural identification of 1–3 together with the antibiotic activities will be presented.
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