Abstract
Fluorescence line narrowing spectrometry is applied to five modifications of DNA (intact adducts) formed from diol epoxides of benzo(a)pyrene, chrysene, 5-methylchrysene, and benz(a)anthracene. The direct identification of all five adducts in a laboratory mixture is accomplished. In addition, a mixture of six corresponding metabolites plus the DNA adducts from benzo(a)pyrene and 5-methylchrysene is resolved. Each adduct can be distinguished from its corresponding tetrol metabolite. Utilization of an intensified diode array-optical multichannel analyzer provides detection of the adduct from benzo(a)pyrene with a S/N approx. 150 for a damage level of approx. 5 bases in 10/sup 6/. 25 references, 7 figures.
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