Abstract
INTRODUCTION: This study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODS: Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing. RESULTS: The bla KPC-2 gene was located between ISKpn6 and a resolvase tnpR in the non-Tn4401 element (NTEKPC-IId). It was detected on a plasmid belonging to the IncQ1 group. CONCLUSIONS To our knowledge, this is the first report of the presence of the bla KPC-2 gene in the NTEKPC-IId element carried by plasmid IncQ1 from infections in Brazil.
Highlights
Introduction: This study investigated the genetic environment of blaKPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates
Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing
The blaKPC-2 gene was located between ISKpn[6] and a resolvase tnpR in the non-Tn4401 element (NTEKPC-IId)
Summary
This study investigated the genetic environment of blaKPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates. Methods: Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing. Conclusions: To our knowledge, this is the first report of the presence of the blaKPC-2 gene in the NTEKPC-IId element carried by plasmid IncQ1 from infections in Brazil.
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