Abstract
Photochemical decomposition of fluvastatin, a medical therapy drug from the group of HMG-CoA reductase inhibitors, has been analyzed. Photodegradation of fluvastatin has been studied in methanol or water solution, in accordance with to the recommendations of the first version of the ICH document. The process has been examined by HPTLC and spectrophotometry. The products of photochemical decomposition of fluvastatin have been separated by HPTLC on a nonpolar octadecyl stationary phase with a mixture of phosphate buffer and methanol as mobile phase. The retention factors of the compounds were described with the aid of the modified Soczewinski-Snyder equation. The UV spectra of unseparated photoproducts were acquired. The photodegradation of fluvastatin, either in water or methanol solutions, has been found to lead to the formation of three photoproducts.
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