Abstract
The cardiac tissue heterogeneity has raised question on the existence of cyclic nucleotide phosphodiesterase (PDE) isozymes, namely PDE1 and PDE5 in cardiomyocytes. PDE isozyme activities were characterized in adult rat left ventricle (LV) whole homogenate by using specific PDE inhibitors. Cardiomyocytes derived from adult rat LV were cultured; PDE activities of cardiomyocyte soluble fraction were resolved by MonoQ HPLC. PDE expression w as investigated by Western blot on cardiomyocyte whole homogenate.
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