Abstract
Introduction and Aim: Obesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth for deaths worldwide. It is considered to be main reason for a number of physiological changes that resulting in many metabolic disorders such as cardiovascular diseases, diabetes, musculoskeletal disorders and various cancer types. Obesity develops from long-termed physiological imbalances in energy expenditure.. One of the therapeutic strategies in managing obesity is inhibition of pancreatic lipase, a key enzyme responsible for the digestion of fats and triglycerides. The aim of the present study was to synthesize silver nanoparticles (Ag-NP) from Ficus racemosa fruit extract and to analyze its activity on pancreatic lipase enzyme using spectroscopic, in vitro and in silico methods.
 Materials and Methods: The phytoconstituent were separated in Ficus racemosa fruit extract by thin layer chromatography technique. The bioactive compound was also identified by gas chromatography-mass spectrometry analysis. Pancreatic lipase inhibition assay was performed in vitro and confirmed by molecular docking analysis. 
 Results: The F. racemosa fruit showed the highest pancreatic lipase inhibitory activity. Molecular docking studies also exhibited good binding affinity of compounds (Diethyl Phthalate) with pancreatic lipase enzymes. 
 Conclusion: Finally, it is concluded that further derivation of such compounds could serve as the new templates for obesity.
Highlights
Introduction and AimObesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth for deaths worldwide
Conclusion: it is concluded that further derivation of such compounds could serve as the new templates for obesity
Our study showed that the synthesized compound, diethyl phthalate have the ability to inhibit the pancreatic lipase enzyme by accommodating itself in ATP-binding pocket which might be a reason for good activity against obesity
Summary
Introduction and AimObesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth for deaths worldwide. Obesity develops from long-termed physiological imbalances in energy expenditure. One of the therapeutic strategies in managing obesity is inhibition of pancreatic lipase, a key enzyme responsible for the digestion of fats and triglycerides. The obesity is generally caused by the combination of excessive food energy intake and lack of physical activity, Genetic factors, medical reasons, or psychiatric illness is the secondary causes. Orlistat (Xenical) is a therapeutic candidate for blocking the dietary fat absorption and seemed to be safe for long term usage. It causes unpleasant side effects (greasy stool), and you need to supplement your diet with fat-soluble vitamins [4]
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