Abstract
A novel metabolite of P. polonicum was recently isolated from Cameroonian Zea mays by means of preparative silica gel thin layer chromatographic method. The potential cytotoxic effects of this novel compound was further tested, in vitro, against cultured human mononuclear lymphocyte cells over 18-hr period in comparison to ochratoxin A and T-2 toxin. At low concentrations (0.15, 0.31 and 0.63 μg/ml), the toxicity of the novel metabolite was similar to that of T-2 toxin, but was found to be significantly (p Key words : Cytotoxicity, cell viability, T-2 toxin, ochratoxin A, nephropathy.
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Schedule a callMore From: International journal of biological and chemical sciences
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