Abstract
Fruits ofSyzygiumjambos(L.) are recognized as a "food", exhibiting significant antidiabetic activities. However, the α-glucosidase inhibition of the components from Syzygiumjambos(L.) have not yet been investigated. In this study,a total of 14 compounds were isolated from Syzygium jambos (L.) Alston, eight of which showed significant inhibitory effects on α-glucosidase, with IC50 values in the range of 0.011-0.665mM. Notably, compounds 1-3 (IC50: 0.013, 0.011 and 0.030mM, respectively) exhibited much stronger activity than acarbose (IC50: 2.329 ± 0.109mM). The enzyme kinetics study indicated that compound 1 was an uncompetitive inhibitor, and compounds 2-8 were mixed-type inhibitors. Moreover, the interactions between compounds and α-glucosidase were investigated by molecular docking, which further revealed that the number of olefin double bonds and 2-COOH of heptadeca-phenols had a notable effect on the α-glucosidase inhibitory activity. This study demonstrated that Syzygiumjambos(L.) fruit might serve as a functional food for the prevention of diabetes mellitus.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
