Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Weigang Zhao ,Samuli Ripatti ,Anas Rasheed ,E Shyong Tai ,Emanuele Di Angelantonio ,Ds Alam ,Wasim Iqbal ,Nh Mallick ,Y.m Teo ,Anne Tybjærg‐Hansen ,Joanna Mccammond Howson ,Shin Maeda ,Rader Dj ,Zia Yaqoob ,Sarju Ralhan ,Hung Yj ,Scott M Damrauer ,J-Mj Juang ,R-H Chung ,Sheu Whh ,Khalid Mehmood ,Marju Orho‐Melander ,Sriha Belguith Asma ,Saied Quraish Kareem Abbas ,I-T Lee ,Js Kooner ,Bf Voight ,J I Rotter ,Won Jae Lee ,Y-Di Chen ,Toshimasa Yamauch ,S S Rasheed ,P Chen ,Salomaa ,Ih Qureshi ,Liang Kw ,Imran Ali ,Alex R Small ,Faisal Majeed ,J.w Jukema ,Philippe Frossard ,Aisha Memon ,Uzma Malik ,Sarah Jabeen ,Roelof A.j Smit ,P.r Kamstrup ,Muredach P Reilly ,Nasir Shah ,T-D Wang ,Solomon Epstein ,Chuan-Yu Hsu ,Emmi Tikkanen ,Olle Melander ,Br Sapkota ,Ep Bottinger ,Naveed Sattar ,Thomas Quertermous ,Xu Guo ,Joseph Lee ,Tahir Saghir ,B.g Nordestgaard ,Shomi Anand ,Tanveer-Us-Salam ,S R Nielsen ,W Zhang ,Nasim Ahmed ,N K Mehra ,Michigan Biobank ,Yunxia Lu ,Praveen Surendran ,Snh Rizvi ,Ca Hsiung ,Nadeem Qamar ,T I Assimes ,Kevin Trindade ,F-U-R Memon ,Taylor Kd ,Jc Chambers ,Dk Sanghera ,T Kadowaki ,Adam S Butterworth ,Rodney Young ,John Danesh ,M Benn ,Minoru Imamura ,Guillaume Paré ,Ruth Frikke‐Schmidt ,Rjf Loos ,Jz Kuo ,Rajiv Chowdhury ,Danish Saleheen

doi:10.17863/cam.15768

Abstract

D.S. has received support from NHLBI, NINDS, Pfizer, Regeneron Pharmaceuticals, Genentech, and Eli Lilly. Genotyping in PROMIS was funded by the Wellcome Trust, UK, and Pfizer. Biomarker assays in PROMIS have been funded through grants awarded by the NIH (RC2HL101834 and RC1TW008485) and Fogarty International (RC1TW008485). The RACE study has been funded by NINDS (R21NS064908), Fogarty International (R21NS064908), and the Center for Non-Communicable Diseases (Karachi, Pakistan). B.F.V. was supported by funding from the American Heart Association (13SDG14330006), the W.W. Smith Charitable Trust (H1201), and the NIH/NIDDK (R01DK101478). J.D. is a British Heart Foundation Professor, European Research Council Senior Investigator, and NIHR Senior Investigator. V.S. was supported by the Finnish Foundation for Cardiovascular Research. S. Ripatti was supported by the Academy of Finland (251217 and 255847), the Center of Excellence in Complex Disease Genetics, the European Union’s Seventh Framework Programme projects ENGAGE (201413) and BioSHaRE (261433), the Finnish Foundation for Cardiovascular Research, Biocentrum Helsinki, and the Sigrid Juselius Foundation. The Mount Sinai IPM Biobank Program is supported by the Andrea and Charles Bronfman Philanthropies. S. Anand is supported by grants from the Canada Research Chair in Ethnic Diversity and CVD and from the Heart and Stroke Michael G. DeGroote Chair in Population Health, McMaster University. Data contributed by Biobank Japan were partly supported by a grant from the Leading Project of the Ministry of Education, Culture, Sports, Science and Technology, Japan. We thank the participants and staff of the Copenhagen Ischemic Heart Disease Study and the Copenhagen General Population Study for their important contributions. The CHD Exome+ Consortium was funded by the UK Medical Research Council (G0800270), the British Heart Foundation (SP/09/002), the UK NIHR Cambridge Biomedical Research Centre, the European Research Council (268834), the European Commission’s Framework Programme 7 (HEALTH-F2-2012-279233), Merck, and Pfizer. PROSPER has received funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-F2-2009-223004.

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