Identification of midbrain dopamine neurons using features from spontaneous spike activity patterns.

Abstract

Although dopamine neurons are considered essential in various brain functions, their specific roles are under debate, partially due to the difficulty to identify dopamine neurons among surrounding neurons deep in the brain based only on the extracellularly recorded electric activities. Thus, a handy method to identify dopamine and non-dopamine neurons based on the spontaneous activity patterns is desired. Here we tried to discriminate optogenetically-identified dopamine neurons from other types of neurons and obtained 86.0% success.