Abstract
Introduction: Metronidazole is an antibacterial, antiprotozoal and amebicidal agent. It has a good activity against pathogenic anaerobic bacteria, low cost, minor adverse effects and a favorable pharmacodynamic and pharmacokinetic properties but still it interacts with many drugs.
 Objective: This study aims to assess the interactions of metronidazole with other drugs at the outpatient setting in Alkharj.
 Methodology: This is a retrospective study include revision of the electronic records in the outpatient setting in a public hospital in Alkharj in order to determine the incidence of interactions between metronidazole and other drugs in 2017.
 Results: In the present study, the concurrent use of metronidazole with azithromycin, ciprofloxacin, domperidone, formoterol and olanzapine may result in increased risk of QT-interval prolongation and arrhythmias. The use of metronidazole with warfarin may result in increased risk of bleeding.
 Conclusion: To dispense and prescribe it appropriately antimicrobial stewardship program should be implemented and checking practice should be implemented to avoid the occurrence of Drug - drug interactions.
Highlights
Metronidazole is an antibacterial, antiprotozoal and amebicidal agent
Drug-drug interactions are a common cause of adverse drug reactions; these interactions are common in patients who received several medications such as elderly [4,5,6,7]
About 57.89 % of the major interactions were caused by metronidazole interaction with ciprofloxacin
Summary
Metronidazole is an antibacterial, antiprotozoal and amebicidal agent It has a good activity against pathogenic anaerobic bacteria, low cost, minor adverse effects and a favorable pharmacodynamic and pharmacokinetic properties but still it interacts with many drugs. Pharmacovigilance aims to identify and quantify the risks that are associated with the medications use, contributing to better understand the main characteristics of adverse drug reactions and the involved mechanisms [1]. These adverse drug reactions represent a common medical problem and can lead to an increased patients’ hospitalizations [2,3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
