Abstract
Method Thirteen patients presenting with immediate symptoms after ingestion of soy formula and IgE reactivity to soy extract were selected after failing oral food challenges. Sixteen patients with no symptoms (negative soy challenge), but presenting with positive specific IgE to soy (ImmunoCAP > 0,35kU/L) were used as controls. In order to allow for simultaneous measurement of IgE responses, a number of purified proteins and protein mixes were used for analysis in a multiplexed capillaryflow based microarray assay.
Highlights
Soy allergy is established as one of the most common food allergies
Significant differences between children with symptoms and without symptoms were found for bconglycinin (Gly m 5) and glycinin (Gly m 6), the storage proteins of soybean. b-conglycinin showed higher response and glycinin, lower response by the tested patients
The highest and most prevalent IgE reacitivity in the group of children with soy allergy was directed to the two storage proteins of soy, b-conglycinin and glycinin
Summary
Soy allergy is established as one of the most common food allergies. we decided to analyze whether there are specific protein markers among Brazilian soy allergic patients, using microarray techniques.Author details 1Federal University of São Paulo, Pediatrics, São Paulo, Brazil. 2Phadia AB, Uppsala, Sweden.Published: 12 August 2011. Identification of marker allergens in Brazilian soy allergic patients Renata Cocco1*, Dirceu Solé1, Marcia Mallozi1, Charles Naspitz1, Fredrik Bernhardsson2, Sigrid Sjolander2, Maryam Poorafshar2, Anita Kober2 From Food Allergy and Anaphylaxis Meeting 2011 Venice, Italy.
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