Abstract
BackgroundThe distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC.MethodsImmunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland.ResultsLMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs.ConclusionsLMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC.
Highlights
The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers
LIM Domain Only 2 (LMO2) is an evolutionarily conserved protein involved in family of the transcription factor necessary for hematopoiesis and angiogenesis [5]
High level of LMO2 has been detected in various organs or tissues including normal glandular cells of the salivary gland according to the publicly available data set of the Human Protein Atlas
Summary
We aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC
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