Abstract
Endocannabinoids and related N-acylethanolamines (NAEs) are lipid mediators involved in a number of physiological and pathological mechanisms in peripheral tissues. Microdialysis (MD) technique all ...
Highlights
Endocannabinoids (ECs) and related N-acylethanolamines (NAEs) are lipid mediators involved in a number of physiological processes
oleoyl ethanolamide (OEA), palmitoyl ethanolamide (PEA) and stearoyl ethanolamide (SEA) could be measured in all MD samples (n=23) and from all the catheter membranes (n=4)
Levels of Arachidonoyl ethanolamide (AEA) could be measured in two microdialysate samples (1.2, 1.5) and detected in three of the four membranes. 2-AG could be measured in all four catheter membranes (241.9-1533.4) and detected in three out of 23 microdialysate samples
Summary
Endocannabinoids (ECs) and related N-acylethanolamines (NAEs) are lipid mediators involved in a number of physiological processes. Arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2AG) are the two most well-studied endogenous cannabis receptor (CB1, CB2) agonists. They are involved in appetite regulation, inflammation, neuroprotection and pain modulation [1,2,3]. PEA modulates pain and inflammation via peroxisome proliferatoractivated receptor type-α (PPAR-α) activation [5,6], and has been suggested to be “a modulator of immune-neural homeostasis” [7]. ECs and endogenous PPAR-α activating NAEs are proposed to be key players as regulators of nociceptive information transmitting from peripheral sites of injury and inflammation to CNS [14,15]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Analytical & Bioanalytical Techniques
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
