Abstract
Parathyroid adenoma (PA) is marked by a certain benign outgrowth in the surface of parathyroid glands. The transcriptome analysis of parathyroid adenomas can provide a deep insight into actively expressed genes and transcripts. Hence, we analyzed and compared the gene expression profiles of parathyroid adenomas and healthy parathyroid gland tissues from Gene Expression Omnibus (GEO) database. We identified a total of 280 differentially expressed genes (196 up-regulated, 84 down-regulated), which are involved in a wide array of biological processes. We further constructed a gene interaction network and analyzed its topological properties to know the network structure and its hidden mechanism. This will help to understand the molecular mechanisms underlying parathyroid adenoma development. We thus identified 13 key regulators (PRPF19, SMC3, POSTN, SNIP1, EBF1, MEIS2, PAX9, SCUBE2, WNT4, ARHGAP10, DOCK5, CAV1 and VSIR), which are deep-rooted from top to bottom in the gene interaction network forming a backbone for the network. The structural features of the network are probably maintained by crosstalk between important genes within the network along with associated functional modules.Thus, gene-expression profiling and network approach could be used to provide an independent platform to glen insights from available clinical data.
Highlights
Parathyroid adenoma (P.A) is marked by a certain benign tumour parathyroid gland
We identified 13 key regulators (PRPF19, SMC3, POSTN, SNIP1, EBF1, MEIS2, PAX9, SCUBE2, WNT4, ARHGAP10, DOCK5, CAV1 and VSIR), which are deep-rooted from top to bottom in the gene interaction network forming a backbone for the network
The structural features of the network are probably maintained by crosstalk between important genes within the network along with associated functional modules.gene-expression profiling and network approach could be used to provide an independent platform to glen insights from available clinical data
Summary
Parathyroid adenoma (P.A) is marked by a certain benign tumour parathyroid gland. Parathyroid glands are four in Number and very small in size, are positioned nearby the backside of the thyroid gland and release parathyroid hormone (PTH). The Parathyroid adenoma outgrowth causes the release of more PTH in the affected gland that it normally should, lead to disruption in calcium and phosphorous levels in the blood. This condition is called hyperparathyroidism [1]. Many studies had been done to study the benign tumours in the parathyroid glands and compare the genetic profiling of parathyroid adenomas and healthy parathyroid tissues [10,11,12,13,14,15,16,17,18,19,20,21]. It is of interest to compare the gene expression profiles of parathyroid adenomas, and healthy parathyroid gland tissues from Gene Expression Omnibus (GEO) is a database [22] followed by network approach which gave us the base to distinguishing the potential pathways and key regulatory genes that may take part in the development of parathyroid adenoma
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