Abstract
Aims: Crohn's disease (CD) is a type of inflammatory bowel disease. The present study aimed to identify key genes and significant signaling pathways associated with CD by bioinformatics analysis. A total of 179 CD patients and 94 healthy controls from nine genome-wide gene expression datasets were included.Results: MMP1 and CLDN8 were two key genes screened from the differentially expressed genes. Connectivity Map predicted several small molecules as possible adjuvant drugs to treat CD. Besides, we used weighted gene coexpression network analysis to explore the functional modules involved in CD pathogenesis. Seven main functional modules were identified, of which black module showed the highest correlation with CD. The genes in black module mainly enriched in interferon signaling and defense response to virus. Blue module was another important module and enriched in several signaling pathways, including extracellular matrix organization, inflammatory response and blood vessel development.Conclusions: This study identified a number of key genes and pathways involved in CD and potential drugs to combat it, which might offer insights into CD pathogenesis and provide a clue to potential treatments.
Highlights
Crohn's disease (CD) is a chronic nonspecific inflammatory bowel disease (IBD), which may affect any region of the gastrointestinal tract intermittently with the terminal ileum and colon being the most common [1]
A large number of remarkably upregulated and downregulated genes were identified through rank aggregation (RRA) analysis, some of which have been reported in previous literature in CD, such as MMP1, MMP3, REG1B,REG1A, CLDN8, GUCA2A
MMP1 and MMP3 belong to the family of metal dependent enzymes, which are capable of degrading a wide range of extracellular matrix components [33]
Summary
Crohn's disease (CD) is a chronic nonspecific inflammatory bowel disease (IBD), which may affect any region of the gastrointestinal tract intermittently with the terminal ileum and colon being the most common [1]. The incidence and prevalence of CD were highest in developed countries, with the highest annual incidence in North America (20.2 per 100,000) and Europe (12.7 per 100,000). The highest worldwide prevalence of CD was found in Europe (322 per 100,000) and. The incidence of CD in the developing countries continues to increase. There was no sex preponderance in adult CD [1].
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