IDENTIFICATION OF INTERLEUKIN-11 AS THE CRUCIAL GENE FOR SUBCHONDRAL BONE MARROW LESION IN OSTEOARTHRITIS THROUGH INTEGRATING ANALYSIS OF BULK AND SINGLE-CELL RNA SEQUENCING ANALYSIS

X Wang,M Zeng,T Chen,Y Xie,J Li,G Ruan,S Xue,H Zhang,C Ding,Z Zhu

doi:10.1016/j.joca.2022.02.489

IDENTIFICATION OF INTERLEUKIN-11 AS THE CRUCIAL GENE FOR SUBCHONDRAL BONE MARROW LESION IN OSTEOARTHRITIS THROUGH INTEGRATING ANALYSIS OF BULK AND SINGLE-CELL RNA SEQUENCING ANALYSIS

X Wang, M Zeng + Show 8 more

Open Access

https://doi.org/10.1016/j.joca.2022.02.489

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Journal: Osteoarthritis and cartilage	Publication Date: Mar 28, 2022
License type: publisher-specific-oa

Affiliation: Zhujiang Hospital, Sun Yat-sen University, First Affiliated Hospital of Anhui Medical University, Anhui Medical University, University of Tasmania

#Bone Marrow Lesions #Bulk RNA + Show 8 more

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Abstract

Purpose: The cellular composition and pathophysiology- related genes of human subchondral bone marrow lesions (BMLs) in knee osteoarthritis (KOA) remain elusive. Here, we performed transcriptomics in both bulk RNA and single-cell levels simultaneously to identify the hub genes and disease-related heterogeneity in BMLs.

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