Abstract
Cells transfer information from the cell surface to the nucleus via signal transduction pathways. Although much is known about the two ends of such pathways, membrane receptors and nuclear transcription factors, the intermediate steps have remained elusive. The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin inhibit conserved elements of signal transduction cascades. The primary drug targets, the immunophilins cyclophilin and FKBP, and the target of the cyclophilin-CsA and FKBP- FK506 complexes, the phosphatase calcineurin, are highly conserved from yeast to human. Studies on immunosuppressant mechanisms of action are providing insights into signal transduction in both yeast and T lymphocytes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
