Identification of human microRNAs targeting Pseudomonas aeruginosa genes by an insilico hybridization method

Abstract

Human microRNAs play crucial role in the modulation of gene expression in case of host pathogen interaction. Infection by Pseudomonas aeruginosa results into dysregulated expression of different microRNAs which modulate the immune response and survival of the pathogen in course of the infection. Evidences of inter-kingdom signaling mediated by short, non-coding RNAs between the human host and Pseudomonas aeruginosa have been found in the previous studies. In this article, an in silico hybridization method was used to identify some candidate human microRNAs having probable binding ability with Pseudomonas aeruginosa mRNAs. The work may provide further insights to the development of novel therapeutics against the pathogen causing multi-drug resistant infections.