Abstract
Bipolar disorder (BD) is a complex mental disorder with high mortality and disability rates worldwide; however, research on its pathogenesis and diagnostic methods remains limited. This study aimed to elucidate potential candidate hub genes and key pathways related to BD in a pre-frontal cortex sample. Raw gene expression profile files of GSE53987, including 36 samples, were obtained from the gene expression omnibus (GEO) database. After data pre-processing, 10,094 genes were selected for weighted gene co-expression network analysis (WGCNA). After dividing highly related genes into 19 modules, we found that the pink, midnight blue, and brown modules were highly correlated with BD. Functional annotation and pathway enrichment analysis for modules, which indicated some key pathways, were conducted based on the Enrichr database. One of the most remarkable significant pathways is the Hippo signaling pathway and its positive transcriptional regulation. Finally, 30 hub genes were identified in three modules. Hub genes with a high degree of connectivity in the PPI network are significantly enriched in positive regulation of transcription. In addition, the hub genes were validated based on another dataset (GSE12649). Taken together, the identification of these 30 hub genes and enrichment pathways might have important clinical implications for BD treatment and diagnosis.
Highlights
Bipolar disorder (BD), like other mental illnesses, is considered a disease caused by abnormal development of the nervous system
After the clinical traits of the samples were introduced into the weighted network (Figure 1), The study found Pink (r = 0.51, P = 0.002) module with 221 genes, brown (r = 0.42, P = 0.01) with 1104 genes, and midnightblue module (r = −0.41, P = 0.02) with 138 genes were highly correlated with the disease
In order to clarify the functional mechanism of targeted modules and diseases, 143 hub genes were uploaded to the Enrichr database for functional annotation
Summary
Bipolar disorder (BD), like other mental illnesses, is considered a disease caused by abnormal development of the nervous system. During the neural development of patients, the ganglion birth and death rates increased (Uribe and Wix, 2012). According to the world health organization (WHO) statistics on BD, it is the sixth leading cause of disability worldwide. The primary symptom of BD is a pathological increase or decrease in emotional activity, and the pathological process is a recurrent episode of mania and depression. The characteristics of mania are high mood, marked acceleration of thinking, and increased verbal movements. Depression often leads to low mood, slow thinking, reduced speech and movement, and loss of
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