Abstract
Chlordane is a bioaccumulative, persistent, and toxic pollutant. Chlordane is one of the 12 priority of Persistent Organic Pollutants (POPs) intended for global action by the United Nations Environment Program (UNEP) Governing Council. POPs are organic compounds resistant to environmental degradation through chemical, biological, and photolytic processes. Chlordane is ubiquitous in air, water, soil, and biological matrices, as well as in major environmental compartments. Chlordane has effects on various organs such as thyroid, bone, skin, kidneys, and blood cells and especially, revealed strong toxicity to liver. In this study, we identified genes related to hepatotoxiciy induced by chlordane in human hepatocellular carcinoma (HepG2) cells using microarray and gene ontology (GO) analysis. Through microarray analysis, we identified 524 up- and 440 down-regulated genes changed by more than 2.0-fold and P-values 0.05 by chlordane. And after GO analysis, we determined several key pathways which known as related to hepatotoxicity such as metabolism of xenobiotics by cytochrome P450, cell cycle, and apoptosis. Thus, our present study suggests that genes expressed by chlordane may provide a clue for hepatotoxic mechanism of chlordane.
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