Abstract
However, this increase did not reach statistical significance (P=O,O6 and 0,09) due to a wide range of the bursting pressure data in both groups. Conclusion:. Administration of the immunosuppressive agent MMF again impairs healing and mechanical stability of colon anastomosis in rats during the early postoperative period, which confirms our previous findings. The growth factor IGF-I tends to neutralize this negative MMF-effect on anastomotic healing with findings of a very similar stability of anastomoses as observed in control (vehicle) animals. These preliminary findings may provide insight into new therapeutic approaches to ensure anastomotic healing in immunocompromised hosts as patient after transplantation or IBD patients on an immunosuppressive regimen.
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