Abstract
The endometrium is prepared for implantation by the actions of estradiol and progesterone. In mice the luminal epithelium only becomes fully receptive to the attaching blastocyst in response to the nidatory estrogen surge on day 4 of pregnancy. The cytokine leukaemia inhibitory factor (LIF) is rapidly induced by nidatory estrogen and has been shown to be the primary mediator of its action. Implantation fails in the absence of LIF and injection of LIF on day 4 of pregnancy can substitute for the nidatory estrogen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.