Abstract
BackgroundTo describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions.MethodsConsecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation on optical coherence tomography (OCT) were enrolled in this cross-sectional study. Included patients were divided into two groups: vitreoretinal interface pathologies group or retinal diseases group. Presence of epiretinal proliferation and its localization within the 9 macular sectors, as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS), were assessed on OCT.Results77 eyes from 69 patients demonstrated epiretinal proliferation on OCT. The most frequently involved ETDRS sector was the 1-mm central subfield, followed by inner temporal and inner nasal sectors. Localization of epiretinal proliferation correlated with the presence of any retinal abnormalities in the same quadrant (r = 0.962; P < 0.0001). 31 eyes (40.3%) demonstrated symptomatic vitreoretinal interface pathologies including lamellar macular hole, full-thickness macular hole, epiretinal membrane and history of macular peeling. 46 eyes (59.7%) manifested various retinal diseases, including age-related macular degeneration, diabetic retinopathy, refractory macular edema, vein occlusion and high myopia.ConclusionsEpiretinal proliferation was noted in several retinal conditions and not limited only to full-thickness and lamellar macular holes. Different mechanisms affecting retinal homeostasis might trigger Müller cells dysregulation, potentially leading to abnormal retinal remodeling.
Highlights
Epiretinal proliferation (ERP) has recently been described in eyes with lamellar macular holes [1]
Since Müller cells may play a central role in retinal homeostasis, we hypothesized that other macular pathologies, besides Lamellar macular hole (LMH) and full-thickness macular holes (FTMH), might develop such proliferative tissue
Included eyes were divided into two groups: vitreoretinal interface (VRI) pathologies group, which included LMH, FTMH, idiopathic epiretinal membrane (ERM) and iatrogenic retinal macular defect, and retinal diseases group which included age-related macular degeneration (AMD), diabetic retinopathy, retinal vein occlusion, refractory chronic macular edema and high myopia
Summary
Epiretinal proliferation (ERP) has recently been described in eyes with lamellar macular holes [1]. This proliferation was distinguished from epiretinal membrane (ERM). While initially suspected to originate from the vitreous, Pang and co-workers noticed that ERP contains mainly Müller glial cells, which makes its genesis from retinal tissue very likely [2, 5]. Since Müller cells may play a central role in retinal homeostasis, we hypothesized that other macular pathologies, besides LMH and FTMH, might develop such proliferative tissue. To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal inter‐ face conditions
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