Abstract
Non-enzymatic glycosylation of proteins results in the formation of advanced glycation end products (AGEs). AGE modification of proteins and thereby damages to cells and tissues have been confirmed to contribute to the pathophysiology of aging and long-term complications of various age-related diseases. Anti-AGEs therapy has thus received significant attention, and several flavonoids including quercetin (1) and (−)-epigallocatechin gallate (EGCG) (2) have shown anti-AGEs activity through trapping and inactivating methylglyoxal (MGO), the crucial intermediate of AGEs formation. However, in the field of MGO-scavenging activity, (−)-epigallocatechin (EGC) (3), one of the key flavonoids in green tea, has received less attention compared with other flavonoids. In this study, we have shown strong MGO-scavenging activity of EGC (3), and EGC (3) was found to be equipotent to previously identified MGO-scavengers such as quercetin (1) and EGCG (2).
Highlights
Advanced glycation end products (AGEs) result from nonenzymatic glycosylation of macromolecules upon exposure to glucose, fructose, and trioses
AGE modification of proteins results in protein dysfunction as well as damage in cells and tissues, and it has been confirmed that AGE-induced damage contributes to the pathophysiology of aging and long-term complications of diabetes [1], neurological diseases [2], atherosclerosis [3], and renal failure [4]
In the course of our ongoing efforts to discover safe MGO-scavengers, it was of our interest to examine MGO-scavenging activity as well as anti-AGEs activity of EGC (3) in comparison with other flavonoids such as epigallocatechin gallate (EGCG) (2) and quercetin (1)
Summary
Advanced glycation end products (AGEs) result from nonenzymatic glycosylation of macromolecules (proteins, phospholipids, and nucleic acids) upon exposure to glucose, fructose, and trioses. Keywords EGC Á EGCG Á Quercetin Á MGO-scavenger Á Advanced glycation end products Á Inhibition & Youhoon Chong chongy@konkuk.ac.kr (-)-Epigallocatechin (EGC) (3, Fig. 1), another major flavonoid rich in green tea, has various health-promoting effects [14, 15], but in the field of MGO-scavenging activity, EGC (3) has received less attention compared with EGCG (2).
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