Abstract
OBJECTIVE: Initially identified as a hypothalamic releasing factor, PACAP has subsequently been discovered to have widespread distribution and function in the reproductive system, including the regulation of gonadotropin biosynthesis and secretion. Previous studies in our laboratory have demonstrated marked induction of PACAP gene expression by GnRH attributable, in part, to CRE and AP-1 sites within region -402 to -77 of the promoter (unpublished data). Loss of GnRH responsiveness was also noted with deletion of nucleotides -915 to -402 in the PACAP promoter.
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