Abstract
In a search for new natural product-derived GABAA receptor modulators, we screened a plant extract library on Xenopus laevis oocytes expressing recombinant α1β2γ2S GABAA receptors, by means of a two-microelectrode voltage clamp assay. A dichloromethane extract of stems and roots of Pholidota chinensis (Orchidaceae) enhanced the GABA-induced chloride current (I GABA) by 132.75%± 36.69% at 100 µg/mL.
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