Abstract
Capillary zone electrophoresis—ionspray mass spectrometry (CZE—IS-MS) in the negative-ion mode was applied in the identification of five organophosphonic acids, which are the primary hydrolysis products of nerve agents. The spectra exhibit a very abundant (M H) − ion with minimal fragmentation. Fragment ions were produced by raising the nozzle — skimmer voltage difference in the first vacuum stage between the atmospheric pressure ion source and the mass analyzer. CZE—IS-MS provides extremely good separation efficiency and very high sensitivity for the phosphoric acids. Sensitivity in the range 10–30 pg was achieved with standard solutions using selected ion monitoring. Linear regression analysis data showed correlation coefficients to be between 0.994 and 0.999, indicating good quantitative linearity of the method.
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