Abstract
Identification of Common Oncogenic Genes and Pathways Both in Osteosarcoma and Ewing's Sarcoma Using Bioinformatics Analysis
Highlights
Osteosarcoma and Ewing’s sarcoma are the two most common primary bone malignancies in children and adolescents [1, 2]
Functional enrichment analysis results showed that hub genes FN1, COL1A1 and COL1A2 were all involved in extracellular matrix, protease binding and ECMreceptor interaction, which could be involved in the development of osteosarcoma and Ewing’s sarcoma
Our findings revealed that common oncogenic genes such as FN1, COL1A1 and COL1A2 and pathways were both in osteosarcoma and Ewing’ s sarcoma
Summary
Osteosarcoma and Ewing’s sarcoma are the two most common primary bone malignancies in children and adolescents [1, 2]. The high morbidity and mortality of these two diseases require more research to characterize and understand their potential molecular mechanisms [5, 6]. The molecular pathways involved in these two diseases will facilitate better treatments. Increasing evidence suggests that many cellular signaling molecules are involved in tumorigenesis, and many specific targets have been identified based on these signaling pathways [7, 8]. At the molecular levels, a common feature of these two diseases is a change in gene expression. Knowledge of the molecular pathogenesis of osteosarcoma and Ewing’s sarcoma is still limited, and good diagnostic and prognostic tools are still lacking
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