Abstract
The impact of respiratory coinfections in COVID-19 is still not well understood despite the growing evidence that consider coinfections greater than expected. A total of 295 patients older than 18 years of age, hospitalized with a confirmed diagnosis of moderate/severe pneumonia due to SARS-CoV-2 infection (according to definitions established by the Ministry of Health of Peru) were enrolled during the study period. A coinfection with one or more respiratory pathogens was detected in 154 (52.2%) patients at hospital admission. The most common coinfections were Mycoplasma pneumoniae (28.1%), Chlamydia pneumoniae (8.8%) and with both bacteria (11.5%); followed by Adenovirus (1.7%), Mycoplasma pneumoniae/Adenovirus (0.7%), Chlamydia pneumoniae/Adenovirus (0.7%), RSV-B/Chlamydia pneumoniae (0.3%) and Mycoplasma pneumoniae/Chlamydia pneumoniae/Adenovirus (0.3%). Expectoration was less frequent in coinfected individuals compared to non-coinfected (5.8% vs. 12.8%). Sepsis was more frequent among coinfected patients than non-coinfected individuals (33.1% vs. 20.6%) and 41% of the patients who received macrolides empirically were PCR-positive for Mycoplasma pneumoniae and Chlamydia pneumoniae.
Highlights
IntroductionCoronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, was declared a pandemic on 11 March 2020 [1]
A total of 295 consecutive patients with a confirmatory diagnosis of COVID-19 were enrolled during the study
Had a confirmatory of 295 consecutive patients with a confirmatory diagnosisdiagnosis of COVID-19 were enrolled during the study period
Summary
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, was declared a pandemic on 11 March 2020 [1]. COVID-19 represents a major public health threat to Latin. America, given that it is considered the most inequitable region in the world according to international indexes [2]. The pandemic has exposed the income inequalities and lack of access to appropriate health care services in Latin America countries [1]. The spread of COVID-19 in Peru overwhelmed the unprepared, precarious and fragmented health system [3]
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