Abstract
04Jan 2018 IDENTIFICATION OF CANCER STEM CELLS IN ORAL SQUAMOUS CELL CARCINOMA USING CRIPTO-1. Yasmine Alaa El-Din , Amina Fouad Farag and Nadia Fathy Hassabou. Assistant Lecturer, Oral Pathology Department, Faculty of Dentistry, October 6 University, Egypt. Lecturer, Oral Pathology Department, Faculty of Dentistry, October 6 University, Egypt.
Highlights
Oral squamous cell carcinoma (OSCC) is still one of the Received: 06 November 2017 Final Accepted: 08 December 2017 Published: January 2018 most common lethal malignancies of the oral cavity
Cripto-1(CR-1) is an identified oncogene which was overexpressed in a wide spectrum of human malignant solid tumours, introducing a potential therapeutic target for human cancers and was significantly associated with initiation and aggressiveness of human cancers
CR-1 was over expressed in well differentiated samples compared to poorly differentiated samples and immunofluorescent expression showed significant decrease in mean percentage (P 0.05)
Summary
Oral squamous cell carcinoma (OSCC) is still one of the Received: 06 November 2017 Final Accepted: 08 December 2017 Published: January 2018 most common lethal malignancies of the oral cavity. Cripto-1 (CR-1), referred to as teratocarcinoma-derived growth factor-1 (TDGF-1), has showed a promising potential as a functional marker for the identification and isolation of CSC from OSCC based on the finding that the CR-1 high OSCC cells express high level of stemness-related genes and possess high potential of self-renewal and high ability of tumorigenesis (Normanno et al, 2004 and Yoon et al, 2011).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
