Abstract
Identification of Broad-Spectrum Beta-lactamase CTX-M-2, CTX-M-8, and Ampc-dependent CMY Genes in Shigella sonnei Isolated from Pediatric Diarrhea Specimens by Multiplex-PCR and Antibiotic Resistance Pattern Determination
Highlights
Shigella species are members of the Enterobacteriaceae family with four groups: group A (Shigella dysentery), group B (Shigella flexneri), group C (Shigella boydii) and group D (Shigella sonnei) [1]
The results indicate a high frequency of CMY gene among Shigella sonnei isolates and higher resistance of these strains was found against erythromycin and cefepime
Careful medical care and proper and timely use of appropriate antibiotics to prevent the spread of resistant isolates seems inevitable
Summary
Shigella species are members of the Enterobacteriaceae family with four groups: group A (Shigella dysentery), group B (Shigella flexneri), group C (Shigella boydii) and group D (Shigella sonnei) [1]. Due to the widespread use of antibiotics, Shigella species have become resistant to many antibiotics, including the third generation of cephalosporins. This issue has made the treatment of this disease difficult [6]. Broad-spectrum betalactamase enzymes (ESBLs) are from class A beta-lactamases that hydrolyze broad-spectrum cephalosporins with a side chain of Oximino, causing bacterial resistance to penicillins, the first, second and third generations of cephalosporins and aztreonam. They are inhibited by beta-lactamase inhibitors such as clavulanic acid [9]. The aim of this study was to determine the frequency of Shigella sonnei strains producing CTX-M-2, CTX-M-8, and CMY beta-lactamase genes by Multiplex PCR and to investigate their association with antibiotic resistance in S. sonnei strains
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