Abstract
Background: Despite the availability of various treatment methods for gastric cancer, herbal medicine remains a promising candidate. This study aimed to identify the bioactive compounds in the hydroalcoholic extract (CHE) of cinnamon (Cinnamomum zeylanicum) using gas chromatography-mass spectrometry (GC-MS) analysis. Objectives: To study the phytochemical constituents from the hydroalcoholic extract (CHE) of cinnamon (Cinnamomum zeylanicum). Methods: The CHE was tested for cytotoxicity against a normal human gastric epithelium cell line (GES‐1) and a human gastric adenocarcinoma cell line (AGS) as a model of gastric cancer. Results: The analysis revealed six main phytochemical compounds in the CHE, with cinnamaldehyde being the predominant compound. The CHE showed potent cytotoxicity against the AGS cell line at concentrations ranging from 100-600 μg/mL, significantly reducing the viability of these cancerous cells to 20.88% compared to the control group (p<0.05). In contrast, the CHE did not significantly affect the viability of GES‐1 cells. Conclusion: The findings obtained suggest a promising avenue for finding new anticancer compounds as potent chemotherapeutic agents for gastric cancer. Keywords: anticancer; bioactive compounds; cinnamon; cytotoxicity
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